Initially, there was a lot of interest in developing good treatments and diagnostic tests I remember being in a meeting where there were 40 vaccine candidates in development. In the case of golf and tennis, media speculated that some absentees were unenthusiastic about competing in any case and used Zika as a convenient excuse. Global and local mapping were presented using the ArcGIS software. Is congenital Zika syndrome being misdiagnosed as something like toxoplasmosis?, Its puzzling that the global trajectory of the disease has looked so different from that in Brazil, he said, and it is urgent to answer the question of why. Not only travellers are at individual risk, but they contribute substantially to the rapid spread [40] by returning to countries where competent vectors are present, thereby providing a source for autochthonous transmission [40]. https://doi.org/10.1371/journal.pntd.0010812.g005. He had a decreased immune system from radiation therapy, which he completed for prostate cancer a month before getting travel-related Zika. We reported the ZIKV infection in 204 countries and territories, which were divided into five regions by the Socio-Demographic Index (SDI), including low, low-middle, middle, high-middle and high SDI regions. If a Zika-infected mosquito bites the human skin, the virus can travel into that person's bloodstream. Zika virus (ZIKV) infection is a mosquito-borne illness and has potential result in severe birth effects. In about 3 percent, the effects include microcephaly. Most of ZIKV infections clustered in Latin America. Low incidence was observed in Africa and Asia, probably due to the likelihood of underdiagnosis, lower risk of ZIKV introduction and immune issues (e.g., due to previous ZIKV infection or cross-protection conferred by previous dengue infections) [28,29]. Certain cities in Europe, North America and Latin America/Caribbean had a high population mobility in ZIKV outbreak areas considered a high risk of imported cases. Due to the severe birth defects associated with ZIKV infection, prevention is necessary and is the most effective approach against ZIKV infection. Moreover, mobility patterns and travel volumes can help to identify the most likely origin of importation and also in predicting further propagation [44]. Vernica Santos spends her days and nights never more than a few feet away from her son, Joo Guilherme, 7, who needs constant help with the most basic living functions. In 2019, ZIKV infection still occurred in 28 countries or territories. Results The search returned 3234 papers, from which 204 were included with a total of 45 646 infants born to mothers with SARS-CoV-2 infection during pregnancy across 36 countries. Yes The virus is still circulating at a low level in Brazil and elsewhere in Latin America, as well as in South and Southeast Asia. Symptoms typically last for 2-7 days. 293 0 obj <>stream Zika virus (ZIKV) is an RNA-enveloped virus that belongs to the Flavivirus genus, and ZIKV infections potentially induce severe neurodegenerative diseases and impair male fertility. Ocular anomalies have been reported among infants with microcephaly in Brazil [2]. March 15, 2023. The research institute where Dr. Ximenes and his colleagues work is cramped and decrepit. Most people with Zika dont show any symptoms. Everyone was basically obliged to work on Covid since 2020, he said. Chronic Bronchitis Facts and Statistics: What You Need to Know, Dementia Facts and Statistics: What You Need to Know, Carpal Tunnel Syndrome Facts and Statistics: What You Need to Know, Breast Cancer Risk From Diethylstilbestrol (DES), What You Need to Know About the Chikungunya Virus, Bronchitis Facts and Statistics: What You Need to Know, 9 Reasons Mosquitoes Bite Some People More Than Others, Heart Valve Disease Facts and Statistics: What You Need to Know, Countries with current or previous Zika virustransmission. Additionally, direct human-to-human transmission of ZIKV occurs not only sexually but perinatally and through breastfeeding or blood transfusion [4], further increasing the disease burden of reproductive age females. This study is a post-hoc analysis of GBD 2019 data, which are available at the Institute of Health Metrics and Evaluation. The proposal includes $144 billion for the Department of Health and Human Services . Global Zika Virus Market Size was estimated at USD 114.13 million in 2022 and is projected to reach USD 141.61 million by 2028, exhibiting a CAGR of 3.13% during the forecast period. In 2019, ZIKV infection occurred in 7 GBD regions and most of them clustered in Latin America. Joo Guilherme receives pro bono physical therapy and audio and visual stimulation every day at a clinic in Recife. The United States and Canada had a large population of international travellers from Latin America/Caribbean in 2019, with almost 7 million people in the top 10 airport pairs. Saving Lives, Protecting People, http://dx.doi.org/10.15585/mmwr.mm6731e1external icon. During the period analyzed, 2016 was the year with the most Zika infections in the North. Some babies with possible Zika infection during pregnancy might look healthy at birth but can develop long-term health problems as they grow. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. You need at least a Starter Account to use this feature. Out of 1,450 babies, approximately 1 in 7 (or 14%) had one or more reported health problems possibly caused by Zika. As soon as this statistic is updated, you will immediately be notified via e-mail. https://doi.org/10.1371/journal.pntd.0010812, Editor: Puneet Bhatt, Army Hospital Research and Referral, INDIA, Received: January 13, 2022; Accepted: September 14, 2022; Published: October 21, 2022. Centers for Disease Control and Prevention (CDC). However, the most current significant outbreak was in India in November of 2021. "There is evidence that suggests patients who receive a COVID-19 vaccine are at an increased risk of myocarditis," Pfizer said according to the documents obtained by Project Veritas. A strikingly large number of the women who had babies with congenital Zika syndrome, at the height of the epidemic, were Black or mixed race, at least in part because both fall disproportionately into the lowest income groups. For the children who have struggled since birth, there is a spectrum of symptoms, Dr. Ximenes said. You can review and change the way we collect information below. Top passenger airport-pairs were obtained from the International Air Transport Association to understand places susceptible to imported ZIKV cases. Zika is a viral infection caused by the Zika virus. Most people with Zika virus infection do not develop symptoms. Whats the difference between them? 4 Biswal S, et al. Zika virus countries 2022. Verywell Health's content is for informational and educational purposes only. Currently, you are using a shared account. Increased connectivity via air travel can facilitate the geographic spread of infectious diseases [39]. Andean Latin America suffered the highest threat of ZIKV infection with an ASR of 98 per 100,000, followed by Central and Tropical Latin America with an ASR over 40 per 100,000 (Table 1 and Fig 1A). Update: Noncongenital Zika virus disease cases 50 U.S. States and the District of Columbia, 2016. Zika is spread mostly by the bite of an infected Aedes species mosquito ( Ae. Brazil registered 19,719 probable cases of Zika in 2022 by the end of July, likely a fraction of those that have occurred. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PLoS Negl Trop Dis 16(10): An SDI of 0 indicated the lowest income, fewest years of schooling and highest fertility, while an SDI of 1 indicates a theoretical maximum [17]. According to the WATS of IATA in 2019, 3 route areas were associated with ZIKV outbreak areas (Latin America/Caribbean): Europe-Latin America/Caribbean, Latin America/Caribbean-North America, and Within Latin America/Caribbean. Visualization, ZIKV transmission has obvious regional and seasonal heterogeneity and is related to environmental changes, especially climate change [33,34]. Low-income women are less likely to have air conditioning, more likely to live at the ground level, more likely to live in areas with poor sanitation, which provide more breeding territory for mosquitoes and thus are more likely to have been bitten. Under 50 years group had a higher proportion of episodes among females, while males had a higher proportion in over 50 plus years group. Symposium participants, as well as . More attention should be given to potential ZIKV outbreak areas. County-level data from 2015 - present (provisional data) are located here. It is difficult to test a vaccine without an active outbreak of the virus, but Dr. Marques said there should be a stockpile of candidate vaccines manufactured and ready to deploy if and when there is another surge of cases. MMWR Morb Mortal Wkly Rep. 2018;67:265269. Is Zika gone, will it come back? For instance, a total of 588 travel-associated ZIKV infection episodes were reported in California during November 2015-September 2017 with most case-patients reporting travel to Mexico and Central America [48]. Those who travel can bring the virus back with them and should use prevention techniques after they return home. [Online]. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China, Roles The first reported cases of Zika in humans were detected in the 1950s and in more recent years outbreaks have been reported in tropical Africa, Southeast Asia, and the Pacific Islands. It is typically found in young adults and teenagers, and is nicknamed the kissing disease because it spreads through saliva and other bodily fluids. y = + x + , where y = ln(ASR) and x = calendaryear. Dengue and the Aedes aegypti mosquito. Are you interested in testing our business solutions? No, Is the Subject Area "Epidemiology" applicable to this article? However, a growing body of evidence suggests that in some severe cases, ZIKV infection can cause neurologic complications and severe fetal outcomes. Acquired hip dysplasia has been described in children with cerebral palsy (CP); periodic surveillance is recommended in this population to prevent hip displacement and dislocation. 261 0 obj <> endobj Middle SDI regions were observed to have the largest number of ZIKV infection episodes. MMWR Morb Mortal Wkly Rep 2020;69:6771. If possible, countries with both warning and stable coping capacity to existing and novel pathogens should pay attention to surveillance of travellers and improve the capacity to detect and respond to infectious disease threats that emerge within their borders [39]. For nonmosquito transmission, ZIKV can also be passed from the mother to the fetus during pregnancy or sexual contact. In Asia there seems to be a wide geographical distribution of ZIKV, whereas in Africa information is limited. To see a map of currently affected areas, visit the CDC's website. But this was turtle speed, not warp speed, he said, and the vaccine candidates never got past Phase 1 before most interest passed. I dont know, Dr. Moreira said. Age group proportions of ZIKV infection episodes in 2011, 2015 and 2019 were presented (Fig 3). From 2011 to 2015, increase in ASR were observed in all GBD regions, especially in Central Latin America (EAPC = 72.37; 95%CI: 16.14 to 155.83) and Tropical Latin America (EAPC = 73.25; 16.78 to 157.02). Globally, the ASR increased by an average of 72.85% (95%CI: 16.47% to 156.53%] per year from 2.09 per 100,000 in 2011 to 20.25 per 100,000 in 2015; subsequently, the ASR decreased with a sizeable fluctuation from 20.25 per 100,000 in 2015 to 3.44 per 100,000 in 2019. DOI: The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Effective prevention of ZIKV infection should be performed at both the personal and integrated levels. https://doi.org/10.1371/journal.pntd.0010812.g002. Zika-microcephaly, the world's largest medical news story in 2016, brought shock, fear, and panic throughout the tropics - coincident with Brazilian assertions' casting the eternally harmless Zika-virus as the ultimate danger to pregnancy: potentially rendering hundreds of millions of women in pregnancy but one mosquito-bite away from . %PDF-1.6 % And all were profoundly disabled, their limbs rigid, their mouths slack, many with foreheads that sloped sharply back above their dark eyes. Pregnancy (from mother or parent to fetus), Barrier-free sex (penis-to-vagina transmission is more likely), Traveling or living in a warm, wet climate, Having unprotected (condomless) sex with an infected partner. Some babies born to mothers with Zika infections had normal head sizes and did not cause concern until they started to miss basic developmental milestones, and scans revealed they did not have key structures in their brains or had severe calcification of brain tissue. In 2016, Zika Strategic Response Plan was published, encouraging the development of surveillance networks, diagnostics, risk communication strategies, and vector-control measures [24,25]. About 5% of babies with birthing parents who had Zika during pregnancy were born with Zika-associated conditions present at birth. Seven years after the first mysterious cases of microcephaly were identified in Brazil, scientists are not much closer to understanding how a virus that was first identified 75 years ago in a forest in Uganda and never known to be harmful, turned up in the northeast of Brazil in 2015. IDA is possible for the first time as a result of FDA's . The peak of the Zika virus outbreak in areas with widespread local transmission occurred in August 2016. World Health Statistics 2022; COVID excess deaths; DDI IN FOCUS: 2022; About WHO; . ZIKV infection is symptomatic in only 2025% of infected individuals who develop a mild and self-limited illness, with an incubation period of 410 days [8]. Yes Brandi is a nurse and the owner of Brandi Jones LLC. 13 April 2016. The brain and eye defects most frequently reported include: corpus callosum abnormalities (problems with the area of the brain that connects the two sides/hemispheres). Dr. Moreira said about one-fifth of the children in the group she has followed since birth have died, many from respiratory infections they contracted after choking on food. Use an Environmental Protection Agency-registered insect repellent when outdoors. The largest proportion was observed in 1549 years group. Most people with Zika virus infection do not develop symptoms; those who do typically have symptoms including rash, fever, conjunctivitis, muscle and joint pain, malaise and headache that last for 2-7 days. The locally acquired cases of Zika reported in the U.S. However, it was not until 2015 that it gained global attention due to a widespread outbreak in Brazil. March 13, 2023. Then you can access your favorite statistics via the star in the header. Higher number of ZIKV infection episodes was observed in females each year (Table 1), with a higher number of females (59.25%) than males (40.75%) in 2019. Chronic Epstein-Barr. Overview and forecasts on trending topics, Industry and market insights and forecasts, Key figures and rankings about companies and products, Consumer and brand insights and preferences in various industries, Detailed information about political and social topics, All key figures about countries and regions, Market forecast and expert KPIs for 600+ segments in 150+ countries, Insights on consumer attitudes and behavior worldwide, Business information on 70m+ public and private companies, Detailed information for 35,000+ online stores and marketplaces. Writing review & editing, Roles Brandi Jones MSN-Ed, RN-BC is a board-certified registered nurse who owns Brandi Jones LLC, where she writes health and wellness blogs, articles, and education. Spain, especially Madrid and Barcelona, suffered the severest threat of imported ZIKV cases with a high international traveller number. ZIKV is a positive sense, single-strand ribonucleic acid (RNA) virus [4]. People assigned female at birth accounted for 3,307 (64%) of the cases. Validation, 0 No, Is the Subject Area "Public and occupational health" applicable to this article? Joo Guilherme now weighs almost as much as his mother does, but he needs her to lift and move him, to attach and clean his feeding tube several times a day, to change his diapers, to suction his throat and to leap up from the floor where she sleeps by his bed and jostle him if an alarm tells her he has stopped breathing in the night. Retrieved March 2023. We were told it was a naturally occurring virus that originated in a wet market in Wuhan, China . Very few of the women who were infected took that test, which left researchers retrospectively trying to establish that they had Zika during their pregnancies. Among the 3 routes, route Latin America/Caribbean-North America had the highest passenger carried number. 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